Scott Hanselman's ComputerZen.com

Some Powershell script code (taken directly from our own ConfigTool/ConfigWebSetup.ps1):

$root = New-Object System.DirectoryServices.DirectoryEntry("IIS://localhost/W3SVC")
$site = $root.get_Children() |Where-Object { $_.ServerComment -eq $AppSiteName }

$webs = $site.get_Children().Find("ROOT", "IIsWebVirtualDir").get_Children()
$web = $webs |Where-Object { $_.get_Name() -eq $AppName }

# $LocalPath = $web.get_Path().Replace("IIS://localhost/", "")
# &C:\WINDOWS\Microsoft.NET\Framework\v2.0.50727\aspnet_regiis -sn $LocalPath
$newScriptMaps = $web.ScriptMaps |ForEach-Object { $_ -replace "Framework\\v\d{1}\.\d{1}\.\d{1,5}\\", "Framework\v2.0.50727\" }
$web.ScriptMaps = $newScriptMaps
$web.CommitChanges()