If you like your things large, mouse cursors or otherwise, like I do, you can make the Windows Caret (the little text flashy inserty thing) wider with this Registry Key on XP:
[HKEY_CURRENT_USER\Control Panel\Desktop]"CaretWidth"=dword:00000003
However, on Vista, hit the Start Menu and type "Ease" to get to the Ease of Access Center then click on "Make things on the screen easier to see" then (here's where it gets lamer) scroll-down.
You'll see "Set the thickness of the blinking cursor. That changes the Registry for you.
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